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I would say that as a preventative measure every 5,000-10,000 miles it would be a waste of money. Some of the better ones (Techron, Seafoam, etc.) do technically work, but the question is weather or not you actually need or would benifit from them.
Better cars, and better fuels mean that the cleaners aren't really needed most of the time. There may be specific situations were they would be of benefit. For instance, if you had some contamination in your fuel (dirt, water, etc.) an additive may help, or if you had old fuel that gummed things up or something like that.
But for the most part, most fuel has lots of detergents and additives in it already. I don't think the vast majority of cars on the road need regular fuel system cleaners or additives. If you are using decent gas it shouldn't ever be a problem.
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